Experience of Surfactant Therapy and Outcome in Preterm Neonates with Respiratory Distress Syndrome

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B.K Ganesh
Adhikari Sudhir
Gauchan Eva


Background: To share the experience and assess the outcome in preterm babies receiving surfactant as prophylactic and rescue therapy.
Methods: Prospective hospital based observa-tional study conducted in the Neonatal intensive care unit of Manipal Teaching Hospital, Pokhara Nepal, and study period was from 1st January 2015 to 31st December 2017. Surfactant was administered to
preterm babies less than 37 weeks with the diagnosis ofrespiratory distress syndrome.
Results: A total of 40 newborns received surfactant of which 19 neonates received prophylactic whereas 21 received rescue therapy .The mean gestation (weeks) was 30.68±1.974 in prophylactic and 32±2.168 in rescue therapy groups. Mean Birth
weight in prophylactic group was 1302.26 ±253.15 grams and 1455.24±344 grams in rescue group. Complications of surfactant administration were noted in 25(62.5%) neonates. Desaturation 13 (52%) and bradycardia 5(20%) were common complications during surfactant administration. Mean hospital stay was 14.26±7.56 (days) in prophylactic and12.52±7.16 (days) in rescue groups (p value 0.46).Difference in duration of continuous positive airway pressure, ventilations, oxygen, requirement of inotropes were also not statically significant.
Conclusions: Rescue surfactant therapy was found to be as effective as prophylactic therapy in preterm babies with respiratory distress syndrome.

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