Prescribing Pattern of Antibiotics in Neonatal Sepsis at Tertiary Teaching Hospital of Birgunj, Nepal

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Singh Smita
Ahmad Md. Parwez
Sinha Ragni
Sarraf Deependra Prasad
Singh Prabin Kumar

Abstract

Background: Neonatal sepsis has been a major cause for mortality, morbidity in neonates especially in developing countries. It needs prompt diagnosis and treatment. Antibiotics have been the mainstay for the treatment. So this study was conducted to
evaluate the prescribing pattern of antibiotics in neonatal sepsis at tertiary teaching hospital of Birgunj, Nepal.
Methods: An observational study was carried for four months in Neonatal intensive care unit of tertiary health center, Birgu.nj. A Perfonna was prepared which contained demographic details of patient, drugs used, drugs prescribed by generic name,
route of administration and duration of hospital stay.
Results: Out of 124 data analyzed in neonates male preponderance was in 64.51 %. The cases of EONS was 45 (72.58 %). There was increased risk for sepsis in preterm (58.06% ), LBW (46.77%) and vaginal delivery (61.29%). The average no of antibiotics per patient was 2.51± 0.79. Most of the neonates received two antibiotics (66%). Amikacin and Cefotaxime was the most frequently prescribed antibiotics. The percentage of prescriptions which contained prescribing by generic name was 58.62. The Mean ± SD duration of NICU stay was 9.23 ± 4.36. There was good survival rate yet the percentage of death was 6.45%.
Conclusion: This study provides a glimpse of antibiotic used in tertiary health center, Birgunj. This study might help in preparing guidelines for rational antibiotic prescribing in neonatal sepsis so that the emergence of antibiotic resistance can be prevented and the cost of treatment can be reduced.

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Research Articles